Possible Interaction: Barium and Calcium Supplement

“However, there is evidence that Ba can weakly mimic Ca , such that I(Ba) inactivation is still a mixture of CDI and VDI.”

“Recent investigations suggest that Ba++ acts by both adding to a calcium (Ca++)-mediated depolarization and reducing potassium (K+) conductance.”

“RESULTS Mineralized nodule formation and the ca cium co ntent of mineralized nodules were increased by BA in a dose-dependent manner.”

“… Ba … Ca resulted in a consistent depolarizing shift of the half-activation potential whose magnitude (∼10 mV) was constant over a range of 2 to 100 … the effects of Ca ions were fully developed at concentrations below 2 mM and indicating that Ba and Ca screened surface charges equally.”

“In addition, the rate of inactivation of Ca-channel current in 10.8mm Ba was also accelerated by adding Ca to the external solution in a concentration-dependent manner.”

“ Ca dilated these vessels and also had a modest inhibitory effect on the contractile response to barium.”

“Replacing Ca with Ba increased the amplitude of the sustained current and decreased its rate of decay.”

“ Barium and strontium but not magnesium can substitute for calcium in potentiating the response.”

“ Barium , but not magnesium, mimicked the effects of calcium on receptor activation.”

“In neurons exposed to glutamate, confocal observation of JC‐1 … comparable changes in mitochondrial morphology that were prevented when barium was … calcium , or following pretreatment with the mPT inhibitor, cyclosporin A. These experiments establish conditions in … mPT could be observed in situ in neurons in response to calcium loading.”