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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ Glycine (100 μM) and baclofen (100 μM) were ineffective as agonists.”
An electrophysiological investigation of the characteristics and function of GABAA receptors on bovine adrenomedullary chromaffin cells“6 Both DAMGO and baclofen reduced the frequency of glycine and GABAA receptor‐mediated mIPSCs without affecting average amplitude, and increased the percentage of failures of the evoked glycine and GABAA receptor‐mediated IPSCs, suggesting a presynaptic site of action.”
“In isolated retinas, baclofen strikingly inhibited the K(+)‐evoked release of glycine but had no effect on GABA release.”
“We suggest that baclofen enhances the light‐evoked release of ACh from amacrine cells by inhibiting glycine release from glycinergic amacrine cells which are stimulated by ACh and form an inhibitory feedback loop to the cholinergic neurones.”
“7 Baclofen (10 μm) significantly reduced the K‐evoked release from cortical slices of glutamate, aspartate, glycine and taurine.”
“This effect of baclofen can be mimicked by a blockers of gamma-aminobutyric acid (GABA) and glycine , suggesting that in these cells baclofen's enhancement is due in part to network effects resulting in a removal of sustained inhibition.”
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