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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Baclofen
supplement:
Glutamic Acid
Research Papers that Mention the Interaction
“Gabapentin, baclofen and CGP 44532 all reduced the electrically stimulated release of [3H]glutamic acid (IC50=20 microM, 0.8 microM and 2 microM, respectively).”
Gabapentin activates presynaptic GABAB heteroreceptors in rat cortical slices.“ Baclofen at a low concentration inhibits only Glu- and Asp-evoked release (total release) due to inhibition of both Ca(2+)-dependent and -independent fractions in the case of Glu and to inhibition of the Ca(2+)-independent fraction in the case of Asp.”
“Ca(2+)-independent release was inhibited: 87 and 88% (Asp), 85 and 95% Glu ) by baclofen 10 and 100 microM respectively.”
“It is concluded that baclofen at a high concentration inhibits the evoked release of Glu , Asp, Tau and Ala due to inhibition of the Ca(2+)-dependent fraction and also of the Ca(2+)-independent component in the case of Glu and Asp.”
“GBP, baclofen , and CGP 44532 all reduced the electrically stimulated release of [3H]glutamic acid [median inhibitory concentration (IC50), 20 μM, 0.8 μM, and 2 μM, respectively).”
Not Another Gabapentin Mechanism!
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