Possible Interaction: Baclofen and Gamma-Aminobutyric Acid

“It has recently been shown that the stimulation of γ‐aminobutyric acid type B (GABAB) receptors by baclofen decreases the rate of transient lower oesophageal sphincter relaxation and increases the lower oesophageal sphincter pressure in healthy humans.”

“ GABAB activation using baclofen further reduced OGD‐induced neuron damage in culture and stroke outcomes of MCAO, relative to Shrm4 alone.”

“Potencies of the full agonists R-(+)-β-(aminomethyl)-4-chlorobenzenepropanoic acid hydrochloride baclofen ) and GABA are increased at the constitutively active versus the corresponding wild-type receptors.”

“Mean GABA level and GAD activity were significantly higher both in tumor and in normal tissue of baclophen treated mice in comparison to control animals.”

“The actions of GABA were mimicked by muscimol on the GABAA receptor and by baclofen on the GABAB receptor.”

“Unilateral injections into the substantia nigra of GABA agonists or the GABA-related agents muscimol (5-50 ng), baclofen (10-50 ng) or B-aminobutyric acid (25-50 ug) induced intensive turning in the direction contralateral to the injected hemisphere.”

“ GABA and GABA-related drugs such as muscimol, gamma-hydroxybutyric acid and baclofen injected unilaterally into the substantia nigra of rats elicited contraversive turning.”

“ Baclofen binds to γ-aminobutyric acid receptors to inhibit both monosynaptic and polysynaptic reflexes at the spinal cord level.”

“ Intrathecal baclofen may inhibit postsynaptic activity and suppress sympathetic activity via the stimulation of γ-aminobutyric acid B receptors the brain.”

“ Oral baclofen replacement with adjunctive administration of parenteral gamma-aminobutyric acid agonists only served to stabilize the patient's critical condition throughout his hospital course.”