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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“In addition, both subjects demonstrated significant increases in cough threshold to inhaled capsaicin after treatment with baclofen.”
Treatment of Chronic, Refractory Cough with Baclofen“RESULTS Subjects receiving ba lofen (n =10) demonstrated a significant elevation of cap saicin co ugh threshold compared with placebo subjects (n=10).”
“Six of 10 subjects receiving baclofen , but none of the 10 subjects receiving placebo, demonstrated a fourfold or greater increase in capsaicin cough threshold (p=0.0054).”
“ baclofen suppressed, in a phaclofen-sensitive manner, the reflex bladder contraction evoked by chemical stimulation (topical capsaicin ) of capsaicin-sensitive bladder afferents.”
Effect of the GABAB antagonist, phaclofen, on baclofen-induced inhibition of micturition reflex in urethane-anesthetized rats“Results:The intensity of heartburn symptom subsequent to capsaicin infusion was significantly greater after pre-treatment of baclofen as compared with the placebo (P=0.03).”
“The frequency of secondary peristalsis subsequent to capsaicin infusion was significantly decreased with baclofen as compared with the placebo (P<0.002).”
Influence of GABA-B Agonist Baclofen on Capsaicin-Induced Excitation of Secondary Peristalsis in Humans
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