Possible Interaction: Baclofen and Calcium Supplement

“ Baclofen and somatostatin, agonists of Gi-coupled receptors, inhibited Ca2+ signals induced by PregS and CIM0216 in mouse dorsal root ganglion (DRG) neurons.”

“The Ca2+ -mediated rebound depolarization following hyperpolarization and the depolarization hump at the beginning of membrane depolarization were also suppressed by baclofen.”

“Thus baclofen increased the Na PIC and decreased the Ca PIC with a net increase in total PIC.”

“In 29.9% of cells, baclofen facilitated the calcium current by 43.5% ± 8.1%.”

“These findings are consistent with a reduction by (–)-baclofen of the influx of calcium through voltage-activated channels in the membrane of group Ia terminations, a proposal which also accounts for the reduction by (–)-baclofen of the release of GABA at axo-axonic depolarizing synapses on these terminations.”

“ Baclofen modulates presynaptic calcium channels as well but also affects release processes downstream from calcium entry.”

“8 Unlike adenosine, baclofen concentration‐dependently reduced the secondary spike size in calcium‐free medium and no sign of recovery was observed during maintained superfusion for up to 45 min.”

“Nanomolar concentrations of baclofen inhibited depolarization-induced influx of calcium.”

“This inhibition was not mediated by GABAA receptors, but baclofen , which binds to the GABA type B (GABAB) receptor and is known to inhibit the Ca current in other systems, was not able to mimic the action of GABA.”

“Nanomolar concentrations of baclofen also inhibited this calcium current by about 60%.”