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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Baclofen
supplement:
4-Hydroxybutyric Acid
Research Papers that Mention the Interaction
“Likely illicit use of BLF with GHB was seen in one case only.”
Baclofen: To Screen or Not To Screen in Postmortem Blood?“Finally, even though GHB appeared to be acting at presynaptic GABAB receptors, GHB and the GABAB agonist baclofen appeared to have opposite potencies for depression of NMDA- vs. AMPA-mediated EPSCs.”
Effects of gamma hydroxybutyric acid on inhibition and excitation in rat neocortex“Respiratory frequency (f) was reduced … (1 mg) but increased after baclofen (0.5 μg), while muscimol (0.5 μg) … GHBA (1 mg) did not affect f. However, GHBA administered repeatedly caused a dose-dependent increase in f.Tidal volume (…) decreased in a dose-dependent fashion after i.c.v.”
“prevented the action of GHB , while the GABA(B) receptor agonist baclofen (5-10 mg/kg) mimicked it.”
“Our findings demonstrate that baclofen antagonises GHB i.v.”
“Results show that baclofen was able to completely prevent GHB seeking behaviour, decreasing the rate of responding to basal values, without showing any reinforcing properties when made contingent on nose-poking response.”
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