Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 months ago

Possible Interaction: Azathioprine and Glucosamine



Research Papers that Mention the Interaction

GlcN non-competitively inhibits basal glucose transport, which in part depends on GlcN-mediated depletion of ATP stores.
Osteoarthritis and cartilage  •  2009  |  View Paper
Furthermore, glucosamine (>0.1 mM) inhibited the extracellular release of granule contents ( ATP and platelet factor 4) and production of thromboxane A2 from ADP-stimulated platelets (p < 0.05).
Inflammation Research  •  2004  |  View Paper
Glucosamine also acutely reduced cellular glucose uptake, glucokinase activity and intracellular ATP levels.
Neuroscience Letters  •  2010  |  View Paper
Conclusions: These observations suggest that glucosamine is likely to exert an inhibitory action on platelets in vivo by suppressing platelet aggregation, ATP release, and thromboxane A2 production.
Inflammation Research  •  2005  |  View Paper
GlcN plus insulin (but not high glucose plus insulin) decreased ATP (10-30%) and UTP (>50%).
Diabetes  •  2000  |  View Paper
Measurement of intracellular ATP demonstrated that the effects of glucosamine were highly correlated with its ability to reduce ATP levels.
We conclude that … administration of glucosamine can rapidly lower cellular ATP levels and affect insulin action in fat cells by mechanisms independent of increased intracellular UDP-N-acetylhexosamines and that increased metabolism of glucose via the hexosamine pathway may not represent the mechanism of glucose toxicity in fat cells.
The Journal of biological chemistry  •  1998  |  View Paper
The retinal content of ATP shows a modest increment after incubation with low concentrations of D-glucosamine (0.5--2.0 mM) and a remarkable fall at higher concentrations.
Biochimica et biophysica acta  •  1975  |  View Paper
Glucosamine and N -acetylglucosamine reduced the cellular ATP level by a mean of 36% and 27% respectively; values reflected in the 32% and 19% loss of total adenine nucleotides caused by these sugars.
Journal of cell science  •  1971  |  View Paper
Glucosamine in the absence or in the presence of low (1 mm) concentrations of glucose caused a significant reduction of the intracellular ATP pool.
The Journal of biological chemistry  •  1969  |  View Paper