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Last Updated: 4 months ago

Possible Interaction: Azathioprine and Fluorides

supplement:

Fluorides

Research Papers that Mention the Interaction

Even though the ATP concentration was independent of the growth rate under these conditions, fluoride produced a characteristic metabolic alteration in these cells.
When fluoride was present during the entire experimental period, HeLa cells maintained an ATP concentration only slightly below control cells; but when fluoride was added to rapidly growing cells, a rapid decrease in cellular ATP was observed.
Experimental cell research  •  1967  |  View Paper
Among the enzymes tested, that of Streptococcus mutans GS-5 was the most sensitive to fluoride, and the initial rate of hydrolysis of ATP was reduced 50% by approximately 3 mM fluoride.
Infection and immunity  •  1987  |  View Paper
ATP hydrolysis by fresh homogenates was 17% more extensive than that of ADP, 76% more extensive than that of 5'-AMP, and was inhibited by fluoride and p-chloromercuribenzoate (PCMB).
The Journal of cell biology  •  1974  |  View Paper
Fluoride however, appeared in some cases to reduce the ATP concentration to a low level an hour or more before exudation finally stopped.
Planta  •  1972  |  View Paper
The PPi driven synthesis of ATP was inhibited by fluoride also, indicatting that the membrane bound inorganic pyrophosphatase may be involved in the energy metabolism in the cell.
Biochemical and biophysical research communications  •  1971  |  View Paper
The cellular ATP concentration is strongly decreased by 3 mM monoiodoacetate and 20 mM fluoride (90%), but much less by 0.1 mM 2,4-dinitrophenol (60%) and by 60 mM acetate (25%).
Biochimica et biophysica acta  •  1969  |  View Paper
The metabolic inhibitors, cyanide and fluoride , depressed both the respiration and the incorporation of P32 into ATP.
Japanese circulation journal  •  1965  |  View Paper
Fluoride increased the specific activity of the lipid P and the steady-state concentration of ATP.
Canadian journal of biochemistry and physiology  •  1957  |  View Paper
When expressed in Escherichia coli fused to a maltose-binding protein, the enzyme catalysed asymmetric cleavage of Ap4A to AMP and ATP which was inhibited at concentrations of F- as low as 3 microM. These are properties characteristic of Ap4A hydrolase (asymmetrical) (EC 3.6.1.
The Biochemical journal  •  1998  |  View Paper
Thus, fluoride induced the mitochondrial dysfunction in cardiomyocytes by damaging the structure of mitochondrial and interfering with the synthesis of ATP.
Biological Trace Element Research  •  2017  |  View Paper
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