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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Azacitidine
supplement:
Tretinoin
Research Papers that Mention the Interaction
“Thus, ASC exposure to RA or BDNF in combination with 5-azacytidine elevated the transcription of the neuronal differentiation markers and improved the viability and integration of ASCs grafted into the mouse brain.”
In vitro neuronal induction of adipose-derived stem cells and their fate after transplantation into injured mouse brain.“As far as the derived ADSCs, RA in combination with 5-azacytidine caused the elevation of expression of MAP2, but reduced the secretion of BDNF.”
“In P19, enhancement on the RA‐induced up‐regulation of CRABP‐I can be observed in cells treated with 5‐azacytidine (5‐AzaC) in conjunction with RA , where partial demethylation in the 5′‐flanking region of CRABP‐I gene is observed.”
Demethylation in the 5′‐flanking region of mouse cellular retinoic acid binding protein‐I gene is associated with its high level of expression in mouse embryos and facilitates its induction by retinoic acid in P19 embryonal carcinoma cells“However, a pre-adipocyte line established following simultaneous exposure to retinoic acid and 5-azacytidine showed strong restriction of both B-tropic and endogenous N-tropic MuLV.”
“Importantly, the combination of azacytidine with retinoids induces dormancy of malignant tumor cells by reinstating the NR2F1-regulated gene program.”
Dormancy programs as emerging antimetastasis therapeutic alternatives
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