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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Auranofin and Tretinoin



Research Papers that Mention the Interaction

CONCLUSIONS AND IMPLICATIONS These findings indicate that auroanofin in combination with low doses of either ATRA or 1,25(OH)2 vit D3 promotes APL cell differentiation by enhancing histone acetylation and the expression of differentiation-associated genes.
KEY RESULTS Treatment with auroanofin and ATRA cooperatively induced granulocytic differentiation of fresh APL blasts isolated from patients and NB4 cells.
British journal of pharmacology  •  2008  |  View Paper
These findings suggest not only that AF induces caspase-3-dependent apoptosis via a mechanism involving ROS, but also that the combined treatment with AF and ATRA induces differentiation of NB4 cells.
Treatment with AF in combination with ATRA markedly increased the number of cells with differentiated features, such as lobed or multiple nuclei and numerous granules and vacuoles.
British journal of pharmacology  •  2004  |  View Paper