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Discover Supplement-Drug Interactions
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Last Updated: 2 months ago
drug:
Auranofin
supplement:
Selenocysteine
Research Papers that Mention the Interaction
“Taken together, our results suggest the strategy to use SeC and AF in combination could be a highly efficient way to achieve anticancer synergism by targeting TrxR.”
“The results showed that SeC and AF synergistically inhibited the cancer cell growth through induction of ROS-dependent apoptosis with the involvement of mitochondrial dysfunction.”
Enhancement of Auranofin-Induced Apoptosis in MCF-7 Human Breast Cells by Selenocystine, a Synergistic Inhibitor of Thioredoxin Reductase“Herein we demonstrate that selenocystine SeC ) could enhance auranofin (AF)-induced A549 human lung adenocarcinoma cell apoptosis in vitro and in vivo through synergetic inhibition of TrxR1.”
“Addition of selenium in the form of selenite or l-selenocysteine to the growth medium significantly reduces the inhibitory action of auranofin on the growth of C. difficile.”
“ Auranofin , an antirheumatic gold compound, is an inhibitor of selenocysteine enzymes, such as thioredoxin reductase and glutathione peroxidase.”
AURANOFIN INCREASES APOPTOSIS AND ISCHAEMIA–REPERFUSION INJURY IN THE RAT ISOLATED HEART
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