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Last Updated: 2 months ago

Possible Interaction: Auranofin and Selenocysteine

supplement:

Selenocysteine

Research Papers that Mention the Interaction

Taken together, our results suggest the strategy to use SeC and AF in combination could be a highly efficient way to achieve anticancer synergism by targeting TrxR.
The results showed that SeC and AF synergistically inhibited the cancer cell growth through induction of ROS-dependent apoptosis with the involvement of mitochondrial dysfunction.
PloS one  •  2013  |  View Paper
Herein we demonstrate that selenocystine SeC ) could enhance auranofin (AF)-induced A549 human lung adenocarcinoma cell apoptosis in vitro and in vivo through synergetic inhibition of TrxR1.
Cell Death and Disease  •  2014  |  View Paper
Addition of selenium in the form of selenite or l-selenocysteine to the growth medium significantly reduces the inhibitory action of auranofin on the growth of C. difficile.
JBIC Journal of Biological Inorganic Chemistry  •  2009  |  View Paper
Auranofin , an antirheumatic gold compound, is an inhibitor of selenocysteine enzymes, such as thioredoxin reductase and glutathione peroxidase.
Clinical and experimental pharmacology & physiology  •  2004  |  View Paper