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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Auranofin and Selenium



Research Papers that Mention the Interaction

Auranofin treatment at concentrations of 10μM and higher concentrations resulted in a ∼68% …) at concentration of 100nM and mitochondrial Bax at 10μM. The supplementation of selenium (100nM) prior to treatment had a generalized protective affect through the restoration … associated improvement in mitochondrial respiration and cellular viability (10µM ∼48% increase).
Biochemical pharmacology  •  2017  |  View Paper
CONCLUSIONS AND IMPLICATIONS As2O3 and auranofin block the metabolism of selenium in A549 cells.
British journal of pharmacology  •  2008  |  View Paper
Auranofin blocks the uptake of selenium and results in the accumulation of the auranofin–selenide adduct in the culture medium.
Moreover, auranofin inhibits the incorporation of radioisotope selenium (75Se) in selenoproteins in both Escherichia coli, the prokaryotic model for selenoprotein synthesis, and C. difficile without impacting total protein synthesis.
JBIC Journal of Biological Inorganic Chemistry  •  2009  |  View Paper
We demonstrate that the role of selenium in the onset of inhibition by AF is catalytic and can be mimicked by an external source of selenium (benzeneselenol).
The Journal of Biological Chemistry  •  2009  |  View Paper