Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 6 months ago

Possible Interaction: Auranofin and Glutathione



Research Papers that Mention the Interaction

The following were used to inhibit GSH and Trx metabolism: buthionine sulfoximine (BSO), a GSH synthesis inhibitor; sulfasalazine (SSZ), an inhibitor of xc– cysteine/glutamate antiporter; auranofin (Au), a thioredoxin reductase inhibitor; or 2-AAPA, a GSH-reductase inhibitor.
Radiation Research  •  2016  |  View Paper
Inhibition of GSH and Trx metabolism with buthionine sulfoximine (BSO) and auranofin (AUR), respectively, induced significant decreases in clonogenic survival compared to either drug alone in FaDu, Cal-27 and SCC-25 HNSCC cells in vitro and in vivo in Cal-27 xenografts.
PloS one  •  2012  |  View Paper
In addition, auranofin increased ROS levels including O2(•-) and induced GSH depletion in mesothelioma cells.
Oncology reports  •  2016  |  View Paper
With respect to the levels of ROS and GSH, Au increased intracellular O2•- in the HeLa cells and induced GSH depletion.
Molecular medicine reports  •  2015  |  View Paper
In this study, we show that the action of auranofin on T cell activation is dramatically influenced by the glutathione levels of the responding cells.
Cellular immunology  •  1993  |  View Paper
In vitro, AFN increased Gclm mRNA levels, intracellular and extracellular GSH levels, and GPx activity.
Oxidative medicine and cellular longevity  •  2019  |  View Paper