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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Auranofin
supplement:
Glutathione
Research Papers that Mention the Interaction
“The following were used to inhibit GSH and Trx metabolism: buthionine sulfoximine (BSO), a GSH synthesis inhibitor; sulfasalazine (SSZ), an inhibitor of xc– cysteine/glutamate antiporter; auranofin (Au), a thioredoxin reductase inhibitor; or 2-AAPA, a GSH-reductase inhibitor.”
Enhancement of Radiation Response in Breast Cancer Stem Cells by Inhibition of Thioredoxin- and Glutathione-Dependent Metabolism“Inhibition of GSH and Trx metabolism with buthionine sulfoximine (BSO) and auranofin (AUR), respectively, induced significant decreases in clonogenic survival compared to either drug alone in FaDu, Cal-27 and SCC-25 HNSCC cells in vitro and in vivo in Cal-27 xenografts.”
“In addition, auranofin increased ROS levels including O2(•-) and induced GSH depletion in mesothelioma cells.”
“With respect to the levels of ROS and GSH, Au increased intracellular O2•- in the HeLa cells and induced GSH depletion.”
“In this study, we show that the action of auranofin on T cell activation is dramatically influenced by the glutathione levels of the responding cells.”
“In vitro, AFN increased Gclm mRNA levels, intracellular and extracellular GSH levels, and GPx activity.”
Thioredoxin Reductase-1 Inhibition Augments Endogenous Glutathione-Dependent Antioxidant Responses in Experimental Bronchopulmonary Dysplasia
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