Possible Interaction: Atropine and Tubocurarine

“It is concluded that the addition of atropine may be unnecessary for prevention of succinylcholine-induced bradydysrhythmias when d-tubocurarine pretreatment is given.”

“One patient in each pretreatment group showed a fall in heart rate to … than 50 beats min-1; two patients in the group who received both d-tubocurarine … atropine , and three patients in the d-tubocurarine only group, showed … fall in heart rate of 25 per cent or more.”

“Spontaneous transwell migration of granulocytes was doubled by tubocurarine combined with atropine (p>0.05).”

“ Atropine increased resting heart rate and blood pressure with tubocurarine to 107 beats min‐1 and 98 mmHg, respectively, in seven subjects.”

“ Atropine and tubocurarine revealed differential inhibitory influences in esophagus or fundus tissues; caffeine and procaine produced similar effects, i.e., potentiation and blockade of the EFS-induced contractile response in these tissues, respectively.”

“Nicotinic receptor antagonist tubocurarine and muscarinic receptor antagonist atropine reversibly decreased the amplitude of the total excitatory postsynaptic potential induced by electrostimulation of the peripheral region in the mechanosensory receptor field of command neurons on the surface of internal organs.”

“ d-Tubocurarine (2.0 μM) attenuated the augmenting effect of atropine on NA release at all frequencies of stimulation whereas it negated the significant effect of atropine on DBH release.”

“Both of these effects were blocked by d‐tubocurarine , while atropine pre‐treatment was ineffective.”

“However, when the effect of endogenous ACh on nicotinic receptors was prevented by (+)‐tubocurarine, atropine enhanced the release.”

“This effect of MCC to increase ACh release from rat hippocampus and frontal cortex was antagonized by the nicotinic antagonists dihydro‐β‐erythroidine and d‐tubocurarine , but not by α‐bungarotoxin or by the muscarinic antagonist atropine.”

“ Atropine sulfate probably inhibits histamine release induced by tubocurarine through the mediation of intracellular cyclic GMP and atropine can be used as a premedicant in cases of general anaesthesia.”

“When atropine sulfate was given in doses over 0.025 mg/kg intramuscularly 30 min before the administration of tubocurarine , the release of histamine induced by tubocurarine was inhibited, compared to the findings in the non-pretreated groups.”