Possible Interaction: Atropine and Secretin

“Except in the rat, stimulation of PES by secretin in a physiological dose is profoundly inhibited by atropine indicating the importance of a cholinergic input.”

“alpha-CGRP, but not beta-CGRP, at higher doses induced gastric contractions and pancreatic protein-rich secretion , which were blocked by atropine.”

“anticipated to cause a release of secretin resulting in a secretin-induced pancreatic secretion of bicarbonate, is strongly influenced by simultaneous administration of atropine , proving that cholinergic mechanisms were involved [6].”

“ Atropine either moderately depressed or did not alter the volume and bicarbonate response to secretin but constantly reduced enzyme secretion.”

“Since the inhibitory effect of atropine on the secretin-stimulated bicarbonate output was statistically significant, the major inhibitory effect of atropine on the potentiation of pancreatic bicarbonate secretion appears to be its effect on the action of secretin.”

“These studies indicate that atropine inhibits the pancreatic effect but not the intestinal release of secretin.”

“A pharmacologic dose of secretin (5.0 μg/kg/hr) resulted in a significant (P<0.05) increase in pancreatic blood flow, which was inhibited by atropine (5.0 μg/kg/hr) infusion.”

“ Secretin increased cholinergic neural secretion with a maximal increase of 190% at 1 μM. This potentiation was blocked by VIP or atropine.”

“The inhibitory effect of secretin and ACh could be relieved by atropine , and by the protein kinase C (PKC) inhibitors staurosporine and 1‐(5‐isoquinolinylsulphonyl)‐2‐methyl‐piperazine (H‐7).”

“In the rat, the treatment with lorglumide (3 mumol/kg) as well as atropine (100 micrograms/kg) did not have effects on basal interdigestive secretion, whereas in guinea pigs only atropine decreased the protein output (41%) and the juice flow (47%) of the basal pancreatic secretion.”