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Possible Interaction: Atropine and Secretin

supplement:

Secretin

Research Papers that Mention the Interaction

Except in the rat, stimulation of PES by secretin in a physiological dose is profoundly inhibited by atropine indicating the importance of a cholinergic input.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society  •  2003  |  View Paper
alpha-CGRP, but not beta-CGRP, at higher doses induced gastric contractions and pancreatic protein-rich secretion , which were blocked by atropine.
Regulatory Peptides  •  2001  |  View Paper
anticipated to cause a release of secretin resulting in a secretin-induced pancreatic secretion of bicarbonate, is strongly influenced by simultaneous administration of atropine , proving that cholinergic mechanisms were involved [6].
European journal of clinical investigation  •  1990  |  View Paper
Atropine either moderately depressed or did not alter the volume and bicarbonate response to secretin but constantly reduced enzyme secretion.
Schweizerische medizinische Wochenschrift  •  1979  |  View Paper
Since the inhibitory effect of atropine on the secretin-stimulated bicarbonate output was statistically significant, the major inhibitory effect of atropine on the potentiation of pancreatic bicarbonate secretion appears to be its effect on the action of secretin.
Pancreas  •  1988  |  View Paper
These studies indicate that atropine inhibits the pancreatic effect but not the intestinal release of secretin.
The American journal of physiology  •  1982  |  View Paper
A pharmacologic dose of secretin (5.0 μg/kg/hr) resulted in a significant (P<0.05) increase in pancreatic blood flow, which was inhibited by atropine (5.0 μg/kg/hr) infusion.
Digestive Diseases and Sciences  •  2005  |  View Paper
Secretin increased cholinergic neural secretion with a maximal increase of 190% at 1 μM. This potentiation was blocked by VIP or atropine.
British journal of pharmacology  •  1999  |  View Paper
The inhibitory effect of secretin and ACh could be relieved by atropine , and by the protein kinase C (PKC) inhibitors staurosporine and 1‐(5‐isoquinolinylsulphonyl)‐2‐methyl‐piperazine (H‐7).
The Journal of physiology  •  1996  |  View Paper
In the rat, the treatment with lorglumide (3 mumol/kg) as well as atropine (100 micrograms/kg) did not have effects on basal interdigestive secretion, whereas in guinea pigs only atropine decreased the protein output (41%) and the juice flow (47%) of the basal pancreatic secretion.
General pharmacology  •  1995  |  View Paper
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