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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“After administration of atropine , heart rate was identical with and without quinidine but the mean normalized velocity of left ventricular dimension shortening was significantly less with quinidine than with placebo (1.28 +/- 0.19 versus 1.44 +/- 0.21, P less than 0.01).”
Effects of oral quinidine on left ventricular performance in normal subjects and patients with congestive cardiomyopathy.“The atrium-specific positive inotropic effects of quinidine were mimicked by atropine , pirenzepine and dimethylphenylpiperazinium but not by nicotine, cytisine and butyrylcholine; the effects of atropine, dimethylphenylpiperazinium and pirenzepine were also blocked by propranolol.”
Mechanisms of the atrium-specific positive inotropic activities of quinidine- and atropine-like agents in rats.“We have examined the effects of acetylcholine on the force of contraction in isolated heart muscle preparations from cats and compared the inhibitory effects of atropine with those of quinidine.”
“ Quinidine reduced the affinity of atropine (Benfey et al, 1979) but not that of [H]QNB (Mirro et al, 1980).”
“The combination of quinidine and atropine had a much less than additive effect and quinidine competitively antagonized the cholinergic blocking effect of atropine (Benfey et al., 1979).”
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