Possible Interaction: Atropine and Potassium

“ Atropine and pirenzepine decrease the potassium concentration of gastric juice.”

“Addition of atropine , a muscarinic ACh receptor antagonist, into the potassium solution reduced the increase in the level of plasma glucose.”

“ Atropine (10(-7) M) caused inhibition of the maximal contraction elicited by potassium to 50.3 +/- 2.6% maximum of control response (P less than 0.001) in TSM from 2ws but had no significant effect in TSM from 10ws (94.6 +/- 4.2% maximum; P = NS vs. control).”

“The ACh output evoked by either 45 or 108 mM potassium was enhanced by atropine.”

“When potassium evoked this type of activity, the addition to the organ bath of hexamethonium, tetraethylammonium, dimethylphenylpiperazinium and atropine , depressed the contractions of smooth muscles and caused small, irregular waves with incomplete relaxations between contractions.”

“ Atropine (3 X 10(-6) M) increased (3.5 to 4-fold) the amount of ACh released by rat's sliced cerebral cortex incubated in a high (23 mM) potassium medium.”

“When the active reuptake of potassium was prevented either by ouabain (which inhibits active transport) or by atropine (which abolishes the stimulation induced loss of potassium) the second phase of vasodilatation was severely reduced, while the initial phase remained virtually normal.”

“Large doses of atropine or hexamethonium decreased the creatinine, sodium and potassium clearances.”

“Addition of atropine , a muscarinic ACh receptor antagonist, into the potassium solution reduced the increase in the level of plasma glucose.”

“The unmasking by eserine, surgical denervation, and potassium ions of the cholinoceptive sites which are sensitive to blockade by atropine is discussed against the background of alterations in ganglionic electrolyte balance and alterations in membrane potentials.”