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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Atropine
supplement:
Polypeptides
Research Papers that Mention the Interaction
“ Atropine inhibited the PP response to electrical stimulation.”
Vagal, cholinergic regulation of pancreatic polypeptide secretion.“Increasing doses of atropine attenuated the ethnic difference in PP (P = 0.01) but not in early insulin secretory responses (P = 0.6), an effect that was not due to differences in gastric emptying rate (acetaminophen test) and/or circulating glucose.”
“Secretion of insulin and PP was inhibited by atropine (both P < 0.001).”
“ Atropine markedly decreased trypsin output (p <0.05) and plasma concentrations of PP (p <0.05) and abolished the cycling of interdigestive pancreatic secretion and motor activity.”
“ Atropine completely blocked PP release and almost abolished CCK release, whereas gastrin output was enhanced.”
“ Atropine 1 mg in the basal state had no effect on the plasma gastrin concentrations but led to significant decrease in plasma PP concentrations.”
“The plasma PP level was markedly increased by MSF, and was antagonized by atropine.”
“ Atropine blocked the release of PP during GRP and neurotensin infusion.”
“Pretreatment by atropine tended to lower the basal plasma PP level and significantly blunted the cerulein-induced PP secretion.”
“Diphenhydramine and atropine both reduce the intestinal inhibitory responses to the three polypeptides without reducing the intestinal inhibitory responses to epinephrine or papaverine.”
“ Atropine also significantly decreased PNS transmission to the islet, as reflected by PP levels similar to those observed with trimethaphan.”
Activation of the parasympathetic nervous system is necessary for normal meal-induced insulin secretion in rhesus macaques.“ Atropine (100 micrograms ILV) significantly reduced the postprandial PP secretion in both the cephalic and the gastrointestinal phases, whereas increased insulin and glucose levels were unaffected.”
“Centrally administered atropine was able to suppress the basal secretion of PP as well as the secretions stimulated by hypoglycemia and food intake.”
“Pretreatment with 20, 100, and 200 micrograms ILV atropine significantly decreased the PP response to insulin-induced hypoglycemia, with the integrated PP response to 58, 32, and 26% of that of controls respectively.”
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