Possible Interaction: Atropine and Oxytocin

“The effects of OT were also blocked by hexamethonium, a ganglionic blocking agent, by atropine , a muscarinic receptor antagonist, and by N(omega)-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthesis.”

“In this study, 2 ng of oxytocin decreased plasma levels of CCK, gastrin and somatostatin, effects that were blocked by pretreatment with atropine.”

“During long-term dehydration both carbachol and atropine intensified the depletion of oxytocin in the hypothalamus as well as in the neurohypophysis.”

“In not dehydrated rats atropine increased the oxytocin activity of the hypothalamus and neurohypophysis; carbachol did not influence the oxytocin potency of the hypothalamus but augmented it in the neurohypophysis.”

“An augmented and prolonged depressor response to oxytocin was seen after atropine , bretylium, tetraethylammonium or decapitation, but not after decerebration, dihydroergotamine or dibenamine.”

“ Atropine , pyrilamine maleate and indomethacin concentration dependently blocked the response of the uterus to acetylcholine (IC50, 4.82 nM), histamine (IC50, 2.49 nM) and oxytocin (IC50, 0.07 nM), respectively, and to aqueous extract.”

“Administration of atropine , a muscarinic cholinergic antagonist, inhibited the effect of oxytocin in three out of five goats.”