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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
Research Papers that Mention the Interaction
“The muscarinic antagonist atropine completely inhibited CCh- and BCh-induced secretion, while the nicotinic antagonist hexamethonium reduced the CCh response by ~45%.”
Cholinergic-induced anion secretion in murine jejunal enteroids involves synergy between muscarinic and nicotinic pathways.“To corroborate a direct action of atropine on nicotinic receptors, we have employed N,N-dimethyl-… receptor agonist; atropine blocked its secretory responses with an IC50 of 2.04 nM. Nicotinic currents, recorded with the whole … technique were blocked by atropine in a concentration-dependent … showing a competitive nature.”
“… nicotinic currents and their downstream consequences (i.e. cytosolic … release) were blocked by nanomolar concentrations of atropine ; although the blockade was partial, it must be considered when using atropine to study cholinergic neurotransmission, … where both nicotinic and muscarinic receptors are present i.e., the adrenal medulla and autonomic ganglia.”
Blockade of nicotinic receptors of bovine adrenal chromaffin cells by nanomolar concentrations of atropine.“Bath applications of the muscarinic antagonist atropine inhibited nicotinic currents dependent on concentration (EC50=24.3 μmol·l−1).”
“The nicotinic antagonists mecamy-lamine, methyllycaconitine, dihydro-&bgr;-erythroidine, and the muscarinic antagonist atropine blocked the depressant effects of the respective agonists.”
“The response was insensitive to the nicotinic antagonist hexamethonium, but was blocked by atropine , a muscarinic antagonist.”
“At high agonist concentration, atropine inhibits alpha4beta4 nicotinic receptor-mediated ion current in a noncompetitive, voltage-dependent way with IC50 values of 655 nM at -80 mV and of 4.5 microM at -40 mV. At low agonist concentration, 1 microM atropine potentiates alpha4beta4 nicotinic receptor-mediated ion current.”
“This inhibitory effect, observed in 68% of cells that responded to the nicotinic agonist, was blocked by atropine and pertussis toxin, whereas the muscarinic agonist-induced increase in [Ca2+]i was blocked by atropine but was pertussis toxin insensitive.”
“Components (i), (iii) and (iv) persisted in the presence of atropine and were inhibited by nicotinic antagonists.”
“It required the activation of the cholinergic system of the heart as inhibition of both nicotinic (10(-7) M hexametonium) and muscarinic cholinoceptors (10(-7) M atropine ) prevented the reaction.”
“TSH suppression was partially prevented by combined therapy with a nicotinic (mecamylamine) and a muscarinic ( atropine ) antagonist.”
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