Possible Interaction: Atropine and Methionine

“This effect proved to be receptor‐mediated because preincubation with 10−5 M atropine shifted the dose‐response curve one order of magnitude rightward.”

“Lower dose neostigmine 10⁻⁷ M ), inhibited electrically induced relaxation over the range of 1-4 Hz, atropine (10⁻⁶ M) almost abolished this inhibitory effect as well as N(G)-nitro-L-arginine (10⁻⁵ M).”

“When transmural nerve stimulation was applied for 5 min, the contraction of the stomach, induced by 10−6 M serotonin, was inhibited by 54% in the presence of atropine and guanethidine and the level of cyclic AMP was increased to 13.0 ± 0.73 pmol/mg protein.”

“ Atropin , amizyl, glypin are shown to decrease the level of methionine- and leucin-enkefalins in the rat brain.”

“Preinfusion with hexamethonium (C6, 10(-4) M) plus atropine (5 x 10(-5) M) reduced the effects of methionine and glutamic acid slightly, and it completely inhibited the effect of acetylcholine (ACh, 10(-6)--10(-3) M).”

“Both resting and evoked ACh efflux were increased by atropine (1.4 × 10 −7 M).”

“Physostigmine (5 x 10-5M) prolonged inhibition of afferent impulses by electrical stimulation of efferent fibres, but atropine (5 x 10-6 M ) blocked it.”

“2) When atropine-sulphate was applied at a concentration of 10−5 M , the specific binding site were completely blocked, whereas uptake into the cell was not influenced.”

“However, preincubation of mesenteric bed with atropine (0.1 μ M), L-NAME (10 −5 M) or indomethacin ( 10−5 M ) prevented this effect of the venom.”

“The effect of S-albuterol on ACh release was variable, and the mean increase induced by 10-5 M was 30.8 ± 16.1% in the presence of atropine.”