Possible Interaction: Atropine and Glycine

“ Glycine currents were inhibited by atropine in an apparently competitive manner and with considerable selectivity of the tropeines for α2 versus α1 subunits.”

“ Atropine increased (P < 0.05) effluent concentrations of serotonin (5-HT), substance P (SP), and glycine during the day and at night.”

“In contrast, atropine, SR 57227A, m-chlorophenylbiguanide, metoclopramide and granisetron are termed glycine-negative, because they decreased the displacing potency of glycine while glycine decreased the displacing potencies of atropine and metoclopramide.”

“In most of the tested nuerons, the excitatory response to ACh (80.3%) and the inhibitory response to Gly (92.6%) could be blocked by their antagonists atropine and strychnine respectively.”

“Responses to glycine microinjected into the dorsal vagal motor nucleus are blocked by the muscarinic antagonist atropine microinjected at the same site; but, unlike responses to glycine in the nucleus tractus solitarii, responses to glycine in the dorsal vagal motor nucleus are not prolonged by physostigmine.”

“The effects of glycine were also prevented by either atropine or haloperidol suggesting an involvement of cholinergic and monoaminergic excitatory neurotransmission to the bladder.”

“4 Atropine selectively antagonized β‐alanine depolarizations of primary afferents and blocked β‐alanine and glycine hyperpolarizations of motoneurones.”