Possible Interaction: Atropine and Gamma-Aminobutyric Acid

“Pretreatment with atropine (10 mg/kg IP) significantly increased the intensity of circling behavior induced by intranigral injections of muscimol and tended to increase the intensity of circling behavior induced by intranigral injections of GABA.”

“The arterial hypotension induced by GABA was prolonged after a high dose of atropine (10 mg/kg i.v.)”

“While denervation by cooling treatment inhibited the sensitivity of the melanophores to GABA, atropine , bicuculline and pentylenetetrazole all inhibited the dispersal responses of the melanophores induced by higher concentrations of GABA.”

“These chemicals included chemicals that could enhance transmission at cholinergic synapses (physostigmine, nicotine), inhibit cholinergic transmission atropine ), stimulate or enhance the effects of GABA (diazepam, muscimol, cis‐4‐aminocrotonic acid), or antagonise the action of GABA (picrotoxin, bicuculline, SR95531).”

“ GABA enhanced the response induced by nerve stimulation but did not antagonize spermine effects; its action was inhibited in presence of atropine and was mimicked by baclofen, a GABAB agonist.”

“The gastrin and somatostatin responses to 10–4 M GABA were completely inhibited by the GABAA antagonist bicuculline (10–5 M) and the cholinergic blocker atropine (10–7 M), whereas the GABAB antagonist CGP 35348 (5 × 10–5 M) was ineffective.”

“Tetrodotoxin (0.5 microM) or atropine (0.1 microM) prevented the bicuculline-sensitive phases of the GABA or muscimol effects on both muscle layers but not the contractile effect of baclofen on the longitudinal muscle layer.”

“Pretreatment with atropine sulfate antagonized the exacerbating effect of GABA on indomethacin-induced ulceration.”

“The inhibitory effects of GABA on both muscle strips were abolished by tetrodotoxin or atropine , but not by bicuculline.”

“GABA injection decreased the effects of the carbachol and atropine injection decreased the effects of the GABA on sodium and potassium excretion.”