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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Several users of cocaine in various European countries have recently developed a central anticholinergic syndrome due to adulteration of cocaine with atropine.”
[Physostigmine for the immediate treatment of a patient with the central anticholinergic syndrome induced by cocaine cut with atropine].“ Atropine blocked the effect of AHN 2-005 and approached significant antagonism of cocaine.”
Place Conditioning and Locomotor Effects of N-Substituted, 4′,4′′-Difluorobenztropine Analogs in Rats“ Atropine pretreatment was only partly effective in blocking the pressor and tachycardic responses to intracisternal injection of cocaine.”
“Administration of cocaine (37 mM) to ATR pretreated animals increased the incidence of cocaine induced respiratory arrest to more than twofold greater than when cocaine was administered in the absence of pretreatment.”
“The reduction in MABP after cocaine in ATR pretreated animals was also significant.”
“These results suggest that ATR enhances the central respiratory toxicity of cocaine by acting synergistically at CVLM chemosensitive sites.”
“Drug interaction studies showed that the antimuscarinics, atropine and scopolamine, potentiated rather than attenuated the locomotor stimulant and cocaine-like discriminative-stimulus effects of cocaine , indicating that the antimuscarinic effects of the 3alpha-diphenylmethoxytropane analogs did not contribute to their diminished cocaine-like activity.”
“ Atropine (10(-6) M) upwardly shifted the dose-response curves of MEG, cocaine , and carbachol but not of procaine.”
“ Atropine (10(-6) M) shifted the concentration-response curve of cocaine , but not those of lidocaine and procaine, rightward, with a pA2 value (7.66) similar to that obtained with carbachol (7.99).”
“Only the higher doses of cocaine induced reflex vagal bradycardia that was blocked by atropine (0.4 mg/kg i.a.).”
“… cocaine was administered … with both atropine and yohimbine, mean arterial blood pressure was increased 44.2 +/- 7.2 mm Hg, heart rate was increased 30 +/- 7.9 beats/… and the rate-pressure product was increased by 72 +/- 10.1%, whereas coronary blood flow was increased only 42.8 +/- 12%.”
“However, when cocaine infusion and atropine pretreatment occurred concurrently, the depression in responding was increased.”
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