Possible Interaction: Atropine and Calcium Supplement

“By contrast, effects on baseline calcium were blocked by preincubation with atropine.”

“The Ca2+ response could partially be blocked by atropine and completely by pirenzepine, a specific muscarinic receptor-type M1 antagonist.”

“ Atropine reverses the calcium rise when added after agonist and prevents the rise when added prior to agonist.”

“ Atropine blocked the stimulatory effects of GRe on jejunal contractility in low-Ca2+ -induced low contractile state; phentolamine, propranolol and l-NG-nitro-arginine blocked the inhibitory effects in high-Ca2+-induced high contractile state, respectively.”

“In a cell line transfected with the m1 muscarinic receptor (M1-CHO), atropine significantly lowered (approximately 60%) AlF4- stimulated Ca2+i elevation.”

“In dispersed rat parotid acini, atropine significantly lowered basal inositol trisphosphate levels and delayed AlF4(-)-stimulated Ca2+i elevation in a dose-dependent manner.”

“Unlabelled atropine inhibited [3H]NMS binding with an IC50 of ca.”

“Both Atr and Ver antagonized calcium noncompetitively.”

“This paradoxical effect of calcium can be prevented, both in vivo and in vitro, by atropine blockade of muscarinic receptors.”

“This paradoxical effect of calcium was prevented by previous infusion of atropine (0.2 mg/kg).”

“Exogenously administered PGE1 or PGE2, like atropine , markedly decreased both the flow and calcium concentration of parasympathetically evoked rat parotid saliva; PGF2 alpha was less effective.”

“PGF2 alpha, like atropine , increased the Ca concentration of such saliva.”

“A small component of the acetylcholine-evoked rise in cytosolic free calcium (approximately 50-100 nM) is independent of extracellular calcium and is unaffected by 0.5 mM hexamethonium, but is totally blocked by 0.5 microM atropine.”