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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Atorvastatin
supplement:
St John's Wort
Research Papers that Mention the Interaction
“Clinical trials indicate …’s wort Hypericum perforatum ), via cytochrome P450 (CYP) and/or P-glycoprotein induction, … concentrations (and/or increases the clearance) of alprazolam, amitriptyline, atorvastatin , chlorzoxazone, ciclosporin, debrisoquine, digoxin, erythromycin, fexofenadine, gliclazide, imatinib, indinavir, irinotecan, ivabradine, mephenytoin, …, omeprazole, oral contraceptives, quazepam, simvastatin, tacrolimus, talinolol, verapamil, voriconazole and warfarin.”
Interactions Between Herbal Medicines and Prescribed Drugs“Physicians and patients should be aware of this interaction and if treatment with a St. John’s wort product is considered necessary, then there may be a need for increasing the dose of atorvastatin.”
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