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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Atorvastatin
supplement:
Ginkgo Biloba Whole
Research Papers that Mention the Interaction
“This study suggests that GBE slightly decreases the plasma atorvastatin concentrations, but has no meaningful effect on the cholesterol-lowering efficacy of atorvastatin.”
“… GBE administration, AUC0–48, …–∞ and Cmax of atorvastatin were reduced by 14.27% (p = 0.005), 10.00% (p = 0.03) and 28.93% (p = 0.002), respectively; Vd/F and CL/F of atorvastatin were increased by 31.95% (p = 0.017) and 6.48% (p = 0.044).”
Effects of Ginkgo biloba extracts on pharmacokinetics and efficacy of atorvastatin based on plasma indices“In contrast, repeated administration of Ginkgo biloba extract for 14 days slightly reduced atorvastatin AUC, possibly as a result of the induction of OATP1B1-mediated hepatic uptake and subsequent biliary excretion [16].”
Atorvastatin–Green Tea Interaction: Possible Mechanisms are Complicated, But Clinical Relevance is Not?
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