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Discover Supplement-Drug Interactions

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Last Updated: 5 months ago

Possible Interaction: Atorvastatin and Ginkgo Biloba Whole

Research Papers that Mention the Interaction

This study suggests that GBE slightly decreases the plasma atorvastatin concentrations, but has no meaningful effect on the cholesterol-lowering efficacy of atorvastatin.
GBE administration, AUC₀₋₄₈, AUC(… C(max) of atorvastatin were reduced by 14.27% (p = 0.005), 10.00% (p = 0.03) and 28.93% (p = 0.002), respectively; …/F and CL/F of atorvastatin were increased by 31.95% (p = 0.017) and 6.48% (p = 0.044).
Xenobiotica; the fate of foreign compounds in biological systems  •  2012  |  View Paper
In contrast, repeated administration of Ginkgo biloba extract for 14 days slightly reduced atorvastatin AUC, possibly as a result of the induction of OATP1B1-mediated hepatic uptake and subsequent biliary excretion [16].
European Journal of Drug Metabolism and Pharmacokinetics  •  2020  |  View Paper