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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Atorvastatin
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Uptake of calcium ions included in atorvastatin molecule induced mitochondrial uncoupling that enhanced the inhibition of the mitochondrial respiratory chain by atorvastatin.”
Atorvastatin affects negatively respiratory function of isolated endothelial mitochondria.“CONCLUSIONS Intensive pretreatment with 60 mg/day at rvastatin ca l cium ca n significantly reduce myocardial infarction related to PCI with good safety in elderly patients with CHD.”
“After a short-term follow-up (12 to 24 months) placebo and low dose atorvastatin showed a similar CAC increase, although 80 mg/daily atorvastatin increased CAC an additional 12-14% over placebo (p<0.001).”
“In the long-term, atorvastatin caused a greater progression of CAC compared to placebo (additional 1.1%, p=0.04).”
“Protein levels and gene expression levels of alpha-defensins 1, 2 and 3 were decreased significantly after a treatment with atorvastatin calcium 20mg daily compared with the patients before the treatment.”
“Moreover, pretreatment with atorvastatin calcium inhibited the PDGF-ββ-treated phosphorylation of PDGFRβ and Akt, whereas atorvastatin calcium did not affect the phosphorylation of PLC-γ1 or (ERK) 1/2.”
Atorvastatin Calcium Inhibits PDGF-ββ-Induced Proliferation and Migration of VSMCs Through the G0/G1 Cell Cycle Arrest and Suppression of Activated PDGFRβ-PI3K-Akt Signaling Cascade“Contrarily, atorvastatin may lead to an increased risk of calcium stones , but when considering its UUa decreasing effect, it may help in reducing the uric acid stone recurrence.”
“ Atorvastatin calcium co-treatment inhibited the phenotype modulation and cytoskeleton rearrangements and improved the expression of contractile phenotype marker proteins such as α-SM actin, SM22α and calponin in comparison with PDGF-BB alone stimulated VSMCs.”
“However, we cannot rule out the action of calcium in the differential activity of atorvastatin.”
“ Atorvastatin attenuated the glutamate‐induced increase of intracellular calcium , which was associated with a modulation of NMDA receptor function.”
“The total calcium density was significantly increased in rabbits treated with atorvastatin compared with rabbits not treated with atorvastatin (1.64 ± 0.90 vs. 0.49 ± 0.35, P < 0.001), but the microcalcification level was significantly lower.”
Atorvastatin Promotes Macrocalcification, But Not Microcalcification in Atherosclerotic Rabbits: An 18F-NaF PET/CT Study.
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