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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Atomoxetine
supplement:
Yohimbine
Research Papers that Mention the Interaction
“Previous work has shown this synergistic effect with atomoxetine (a NET receptor blocker) and yohimbine (an alpha-2 adrenergic antagonist), which resulted in increased BP [3].”
Polypharmacy: droxidopa to treat neurogenic orthostatic hypotension in a patient with Parkinson disease and type 2 diabetes mellitus“In conclusion, … combination of yohimbine and atomoxetine had a synergistic effect on blood pressure and orthostatic tolerance in peripheral autonomic failure, which may be explained by an increased release of norepinephrine in peripheral sympathetic neurons by &agr;-2 antagonism combined with a reduced norepinephrine clearance by norepinephrine transporter blockade.”
“We hypothesized that increasing residual sympathetic outflow with the &agr;-2 antagonist yohimbine would potentiate the pressor effect of norepinephrine transporter blockade with atomoxetine and improve orthostatic tolerance in peripheral autonomic failure.”
“ Atomoxetine and guanfacine reduced premature responses, while yohimbine bi-phasically affected this index of motor impulsivity.”
Noradrenergic contributions to cue-driven risk-taking and impulsivity.
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