Possible Interaction: Atenolol and Epinephrine

“When the subjects were pretreated with atenolol , the adrenaline increased SBP by 16 mm Hg, the DBP did not change, HR and SV increased by 19 and 30%, and TPR fell.”

“However, atenolol did prevent the effects of epinephrine on left ventricular dimensions and left ventricular performance at the lower infusion rates and significantly blunted these effects at the highest infusion rate.”

“Combined treatment with atenolol and adrenaline resulted in additive effects up to 180 min, and the early pressure upswing recorded with adrenaline was completely abolished.”

“The stimulatory action of adrenaline on colon cancer growth was blocked by atenolol and ICI 118,551, a β(1)- and β(2)-selective antagonist, respectively.”

“ Atenolol in equimolar concentration also attenuated epinephrine-mediated effects, but the effects of atenolol were less marked than those of carvedilol (P < 0.01).”

“Electromechanical dissociation (EMD) occurred in a 20-year-old woman 48 hours after an overdose of atenolol , despite intensive treatment of the beta-blocker poisoning (gastric lavage, charcoal, glucagon, epinephrine , atropine, correction of electrolyte abnormalities, administration of fluids, cardiac pacing, and mechanical ventilation).”

“It remains speculative whether this selective effect of atenolol on epinephrine secretion contributes to its hypotensive action and to its cardioprotective effects in the long term.”

“These results suggest that treatment of patients with primary hypertension with the beta 1-adrenoceptor blocker atenolol inhibits the adrenomedullary secretion of epinephrine , but it does not affect the biochemical indices of sympathoneural activity.”

“Unexpectedly, in atria from patients treated with the beta 1-selective antagonist atenolol , contractile responses to adrenaline are markedly and selectively augmented through activation of beta 2-adrenoceptors.”

“Experimentally was proved that atenolol mimics the trophotropic effects of epinephrine and these effects of epinephrine is realized primarily through β1-adrenergic receptors.”

“However, ATEN , even at concentration as low as 0.01 nM completely abolished epinephrine (1 μM)-induced glucose production in trout hepatocytes.”