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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Atenolol
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“A marked interaction of atenolol is found when calcium or aluminium hudroxide are concurrently administered with the beta blocker whereas Cimetidine does not influence atenolol kinetics.”
Clinical pharmacokinetics of atenolol — A review“ Calcium … atenolol kinetics distinctly: mean peak plasma levels of atenolol fell 51% (P < 0.001), AUC0‐∞ fell from 5818 to 3935 ng ml−1 hr (P < 0.01) and elimination half‐life (t½) increased to a mean of 11.0 hr (compared to 6.2 hr with atenolol alone).”
“Hydrophilic and selective atenolol , which does not possess a histamine-liberating effect, decreases spontaneous transfer of the intracellular calcium , decreases the disorder of the mast-cell membranes, and together with exaprolol and propranolol inhibits, in dose-dependence way, the gain of extracellular histamine in cells.”
[Analysis of the adverse effects of drugs at the cellular and subcellular levels].
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