“For …, ADMA promotes eNOS uncoupling, which, through a vicious … of reactive oxygen species (ROS) formation, tetrahydrobiopterin oxidation , and peroxynitrite formation, leads to overt endothelial dysfunction and an impaired vascular regenerative capacity.2 Moreover, it has been observed that ADMA has prooxidative and proinflammatory effects in cells lacking NO formation.”