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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Asymmetric Dimethylarginine and Telmisartan

Research Papers that Mention the Interaction

Because aging of endothelial cells (ECs) is hallmarked by a reduction in NO synthesis, we hypothesized that telmisartan increases NO formation by regulated asymmetrical dimethylarginine (ADMA)-dimethylarginine dimethylaminohydrolase (DDAH)-system through blocking AT1R and activating PPARγ signaling.
We have demonstrated that telmisartan mainly by activating PPARγ signaling can alter the catabolism and release of ADMA as an important cardiovascular risk factor.
Hypertension  •  2008  |  View Paper
Reactive hyperemia was found to be greater, whereas plasma levels of ADMA were lower after telmisartan as compared with valsartan treatment, despite a similar BP reduction exerted by both compounds.
American journal of hypertension  •  2007  |  View Paper
The reduction in plasma ADMA levels may contribute to this more favorable effect of telmisartan.
American journal of hypertension  •  2007  |  View Paper
We found that the concentrations of ADMA were significantly elevated in the plasma of diabetic rat models, and were significantly reduced by benazepril or telmisartan.
Experimental eye research  •  2009  |  View Paper