Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Asymmetric Dimethylarginine and Simvastatin

Research Papers that Mention the Interaction

Moreover, in vivo, ADMA administration reduced Matrigel plug angiogenesis in wild‐type mice and decreased simvastatin‐induced eNOS phosphorylation in aortas of apolipoprotein E–deficient mice, but not endothelial DDAH‐2‐overexpressed aortas.
Journal of the American Heart Association  •  2016  |  View Paper
In an ADMA loading experiment, simvastatin treatment resulted in a decrease in ADMA content, an indication of increased DDAH activity.
American journal of physiology. Heart and circulatory physiology  •  2010  |  View Paper
Because raised ADMA is known to prevent the favorable effect of statins on myocardial blood flow, cointerventions aimed at lowering or antagonizing ADMA may either prompt or potentiate the cardiovascular protective effect of simvastatin.
Journal of nephrology  •  2008  |  View Paper
As NO-mediated effects may play a major role in the therapeutic effects of statins, ADMA concentration is an important factor that influences the "pleiotropic" effects of simvastatin.
Journal of the American College of Cardiology  •  2007  |  View Paper
Simvastatin (0.1, 0.5, or 2.5 micromol/L) markedly inhibited the elevated concentrations of TNF-alpha and sICAM-1, the activity of NF-kappaB, and the phosphorylation of p38 MAPK and ERK(1/2) induced by ADMA.
Biochemistry and cell biology = Biochimie et biologie cellulaire  •  2007  |  View Paper
ADMA and inducible nitric oxide synthase were reduced by simvastatin , but eNOS was increased.
American journal of respiratory cell and molecular biology  •  2011  |  View Paper