supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Asymmetric Dimethylarginine
Research Papers that Mention the Interaction
“The vasoactive potencies of ADMA (concentration for half-maximal effect with the endothelium intact 25.4 ± 7.1 μmol/l) and L-NMMA (concentration for half-maximal effect with the endothelium intact 8.2 ± 2.9 μmol/l) was significantly (P < 0.05) greater than that of SDMA.”
“These findings reveal the dynamic interplay between different arginine methylation types in the cells, and that the pre-existence of the dominant ADMA mark can block the occurrence of SDMA and MMA marks on the same substrate.”
Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs“The increase in endothelium‐derived ADMA following co‐incubation with l‐NMMA is consistent with competition between ADMA and l‐NMMA for dimethylarginase.”
“Interestingly, we found that the amounts of MMA and SDMA are about fourfold higher than those of ADMA in N2 protein lysates using acid hydrolysis.”
PRMT-5 converts monomethylarginines into symmetrical dimethylarginines in Caenorhabditis elegans“These observations provide support for the hypothesis that L-NMMA and ADMA selectively block basal over agonist-stimulated activity of nitric oxide in rat vessels.”
“Exogenously applied authentic L‐NMA and ADMA (1 – 100 μM) concentration‐dependently inhibited the EFS‐induced urethral relaxation in the control group.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback