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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Asymmetric Dimethylarginine
drug:
Atorvastatin
Research Papers that Mention the Interaction
“ Atorvastatin significantly lowered total cholesterol, LDL cholesterol, and ADMA after 1 day of treatment, while triglycerides, ApoB and hsCRP were lowered after 3 months.”
Effect of acute changes in oxygen tension on flow-mediated dilation. Relation to cardiovascular risk“Both rosuvastatin and atorvastatin decreased plasma ADMA levels; rosuvastatin had a significantly greater effect.”
“ ADMA concentration of cardiac tissues was also significantly reduced in the high-dose atorvastatin group.”
“ConclusionIn rats with dyslipidemia, atorvastatin therapy could reduce plasma level of ADMA and ADMA concentration in cardiac tissues, and these effects are associated with the dose of atorvastatin therapy.”
Atorvastatin protects endothelium by decreasing asymmetric dimethylarginine in dyslipidemia rats“Nevertheless, in comparison to control group, NO production was profoundly increased and serum levels of MDA, CRP and ADMA were significantly decreased with atorvastatin or rosiglitazone therapy.”
“Insulin-resistant rats exhibited not only decreases in the DDAH activity and aortic expression of DDAH1 and sterol regulatory element-binding protein 1 (SREBP1) but also increases in plasma ADMA levels, all of which were inhibited by atorvastatin.”
“ Atorvastatin administration significantly reduced the ADMA levels without affecting the levels of plasma lipids.”
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