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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Asymmetric Dimethylarginine
Research Papers that Mention the Interaction
“Angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker (ARB) are reported to reduce the serum ADMA level.”
Effects of Candesartan Cilexetil Compared with Amlodipine on Serum Asymmetric Dimethylarginine Levels in the Chronic Stage of Cerebral Infarction: A Preliminary Study.“… angiotensin receptor blockers (… ADMA levels, but no study has compared the effect of these drugs in patients with ESRD on maintenance hemodialysis (MHD).MethodsWe evaluated the effect …), and placebo on ADMA levels in 15 patients on MHD in a double-blind, placebo-controlled, three x three cross-over study.”
“Moreover, small clinical studies have shown that treatment with angiotensin receptor blockers also reduces the circulating levels of asymmetric dimethylarginine ( ADMA), an endogenous inhibitor of nitric oxide (NO) synthase.”
“Angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers , and antioxidants are effective inhibitors of the adverse effects of ADMA.”
“The increased ROS production induced by ADMA was markedly inhibited by the angiotensin II receptor-blocker telmisartan , the angiotensin-converting enzyme inhibitor benazepril, the reduced form of nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase inhibitor diphenyliodonium (DPI), or the antioxidant and free-radical scavenger N-acetyl-l-cysteine (NAC).”
Effects of asymmetric dimethylarginine on bovine retinal capillary endothelial cell proliferation, reactive oxygen species production, permeability, intercellular adhesion molecule-1, and occludin expression
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