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Last Updated: 3 months ago

Possible Interaction: Aspirin and Vitamin E

drug:

Aspirin

supplement:

Vitamin E

Research Papers that Mention the Interaction

Based on the results of the present study and the ATBC Study, we conclude that alpha-tocopherol supplementation may increase the risk of clinically important bleedings, particularly when combined with ASA.
The highest risk of gingival bleeding was among those who took both alpha-tocopherol and ASA (33.4% of probed sites bleeding vs 25.8% among subjects taking neither alpha-tocopherol nor ASA, P < 0.001).
Annals of medicine  •  1998  |  View Paper
Preliminary results show a significant reduction in the incidence of ischemic events in patients in the vitamin E plus aspirin group compared with patients taking only aspirin.
There was a highly significant reduction in platelet adhesiveness in patients who were taking vitamin E plus aspirin compared with those taking aspirin only.
We concluded that the combination of vitamin E and a platelet antiaggregating agent (eg, aspirin ) significantly enhances the efficacy of the preventive treatment regimen in patients with transient ischemic attacks and other ischemic cerebrovascular problems.
The American journal of clinical nutrition  •  1995  |  View Paper
Vitamin E increased the effect of acetylsalicylic acid on neutrophil nitric oxide production 42-fold (P<0.05).
Vitamin E potentiated the antiplatelet effect of acetylsalicylic acid in both whole blood and PRP.
We conclude that vitamin E potentiates the antiplatelet effect of acetylsalicylic acid in vitro, and thus merits further research in ex vivo studies.
Platelets  •  2005  |  View Paper
Vitamin E should not be used in patients who have bleeding disorders or patients on anticoagulants or acetylsalicylic acid (ASA).
MedGenMed : Medscape general medicine  •  2004  |  View Paper
BACKGROUND AND OBJECTIVES The combination of vitamin E with aspirin is becoming an attractive therapeutic approach to prevent thrombotic vascular accidents.
INTERPRETATION AND CONCLUSIONS These data demonstrate that vitamin E can potentiate the antiplatelet activity of aspirin by inhibiting the early events of platelet activation pathways induced by collagen.
INTERPRETATION AND CONCLUSIONS These data demonstrate that vitamin E can potentiate the antiplatelet activity of aspirin by inhibiting the early events of platelet activation pathways induced by collagen.
In this study we investigated the capacity of vitamin E (50 and 100 M) to enhance the antiplatelet effect of aspirin.
In this study we investigated the capacity of vitamin E (50 and 100 M) to enhance the antiplatelet effect of aspirin.
The combination of vitamin E with aspirin is becoming an attractive therapeutic approach to prevent thrombotic vascular accidents.
This finding provides a rationale for combining aspirin and vitamin E to prevent thrombotic complications in atherosclerotic patients.
Haematologica  •  2002  |  View Paper
When alpha-tocopherol (20 micrograms/ml) and aspirin (0.5 mM), or alpha-tocopherol and the mixture of phosphocreatine (1.5 mM) and creatine phosphokinase (50 U/ml) (CP/CPK) were added to this reaction system, a synergic inhibitory effect on aggregation was observed.
Thrombosis research  •  1990  |  View Paper
Preincubation with the lipoxygenase inhibitor 5,8,11,14-eicosatetraynoic acid (ETYA) completely abolished this arachidonate-induced tocopherol oxidation whereas cyclooxygenase inhibitors (indomethacin and aspirin ) further potentiated tocopherol oxidation , indicating that this oxidation is closely linked with platelet 12-lipoxygenase activity.
The Journal of biological chemistry  •  1990  |  View Paper
The total average PI score of the right and left uterine arteries in groups receiving vitamin E in accompanied with aspirin was lower than the two counterparts significantly (p<0.001).
The total average PI score of the right and left uterine arteries in groups receiving vitamin E in accompanied with aspirin was lower than the two counterparts significantly (p<0.001).
The women receiving vitamin E in accompanied with aspirin had the least mean PI of the uterine artery (p<0.001).
International journal of reproductive biomedicine  •  2017  |  View Paper
These effects could be limited by the use of tocopherol and acetylsalicylic acid.
Annals of agricultural and environmental medicine : AAEM  •  2014  |  View Paper
Vitamin E plus aspirin may increase the tendency to hemorrhage, which makes a lower upper intake level worth consideration.
The American journal of clinical nutrition  •  2001  |  View Paper
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