Possible Interaction: Aspirin and Vitamin E

“Based on the results of the present study and the ATBC Study, we conclude that alpha-tocopherol supplementation may increase the risk of clinically important bleedings, particularly when combined with ASA.”

“The highest risk of gingival bleeding was among those who took both alpha-tocopherol and ASA (33.4% of probed sites bleeding vs 25.8% among subjects taking neither alpha-tocopherol nor ASA, P < 0.001).”

“Preliminary results show a significant reduction in the incidence of ischemic events in patients in the vitamin E plus aspirin group compared with patients taking only aspirin.”

“There was a highly significant reduction in platelet adhesiveness in patients who were taking vitamin E plus aspirin compared with those taking aspirin only.”

“We concluded that the combination of vitamin E and a platelet antiaggregating agent (eg, aspirin ) significantly enhances the efficacy of the preventive treatment regimen in patients with transient ischemic attacks and other ischemic cerebrovascular problems.”

“These effects could be limited by the use of tocopherol and acetylsalicylic acid.”

“ Vitamin E plus aspirin may increase the tendency to hemorrhage, which makes a lower upper intake level worth consideration.”

“In fact, one study suggests that aspirin plus vitamin E is more effective than aspirin alone.”

“ Vitamin E increased the effect of acetylsalicylic acid on neutrophil nitric oxide production 42-fold (P < 0.05).”

“ Vitamin E potentiated the antiplatelet effect of acetylsalicylic acid in both whole blood and PRP.”

“Vitamin E spared or even increased prostacyclin levels, and acetylsalicylic acid + vitamin E diminished the inhibition of prostacyclin synthesis by acetylsalicylic acid (IC50 acetylsalicylic acid alone = 1.81 ± 0.15 µM; IC50 acetylsalicylic acid + vitamin E = 12.92 ± 1.10 µM, P < 0.05).”

“We conclude that vitamin E potentiates the antiplatelet effect of acetylsalicylic acid in vitro, and thus merits further research in ex vivo studies.”

“ Vitamin E should not be used in patients who have bleeding disorders or patients on anticoagulants or acetylsalicylic acid (ASA).”

“BACKGROUND AND OBJECTIVES The combination of vitamin E with aspirin is becoming an attractive therapeutic approach to prevent thrombotic vascular accidents.”

“INTERPRETATION AND CONCLUSIONS These data demonstrate that vi amin E ca n potentiate the antiplatelet activity of asp irin by inhibiting the early events of platelet activation pathways induced by collagen.”

“In this study we investigated the capacity of vitamin E (50 and 100 M) to enhance the antiplatelet effect of aspirin.”

“This finding provides a rationale for combining aspirin and vitamin E to prevent thrombotic complications in atherosclerotic patients.”

“When alpha-tocopherol (20 micrograms/ml) and aspirin (0.5 mM), or alpha-tocopherol and the mixture of phosphocreatine (1.5 mM) and creatine phosphokinase (50 U/ml) (CP/CPK) were added to this reaction system, a synergic inhibitory effect on aggregation was observed.”

“The use of such pharmacological agents as vitamin E, ASA, and combination of ASA and vitamin E , inhibited formation of the AGEs in 13‐day‐old embryos and reduced the AGEs level in embryos after 19 d of the development.”