Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 4 months ago

Possible Interaction: Aspirin and Vitamin E

drug:

Aspirin

supplement:

Vitamin E

Research Papers that Mention the Interaction

Based on the results of the present study and the ATBC Study, we conclude that alpha-tocopherol supplementation may increase the risk of clinically important bleedings, particularly when combined with ASA.
The highest risk of gingival bleeding was among those who took both alpha-tocopherol and ASA (33.4% of probed sites bleeding vs 25.8% among subjects taking neither alpha-tocopherol nor ASA, P < 0.001).
Annals of medicine  •  1998  |  View Paper
Preliminary results show a significant reduction in the incidence of ischemic events in patients in the vitamin E plus aspirin group compared with patients taking only aspirin.
There was a highly significant reduction in platelet adhesiveness in patients who were taking vitamin E plus aspirin compared with those taking aspirin only.
We concluded that the combination of vitamin E and a platelet antiaggregating agent (eg, aspirin ) significantly enhances the efficacy of the preventive treatment regimen in patients with transient ischemic attacks and other ischemic cerebrovascular problems.
The American journal of clinical nutrition  •  1995  |  View Paper
Vitamin E increased the effect of acetylsalicylic acid on neutrophil nitric oxide production 42-fold (P<0.05).
Vitamin E potentiated the antiplatelet effect of acetylsalicylic acid in both whole blood and PRP.
We conclude that vitamin E potentiates the antiplatelet effect of acetylsalicylic acid in vitro, and thus merits further research in ex vivo studies.
Platelets  •  2005  |  View Paper
Vitamin E should not be used in patients who have bleeding disorders or patients on anticoagulants or acetylsalicylic acid (ASA).
MedGenMed : Medscape general medicine  •  2004  |  View Paper
BACKGROUND AND OBJECTIVES The combination of vitamin E with aspirin is becoming an attractive therapeutic approach to prevent thrombotic vascular accidents.
INTERPRETATION AND CONCLUSIONS These data demonstrate that vitamin E can potentiate the antiplatelet activity of aspirin by inhibiting the early events of platelet activation pathways induced by collagen.
INTERPRETATION AND CONCLUSIONS These data demonstrate that vitamin E can potentiate the antiplatelet activity of aspirin by inhibiting the early events of platelet activation pathways induced by collagen.
In this study we investigated the capacity of vitamin E (50 and 100 M) to enhance the antiplatelet effect of aspirin.
In this study we investigated the capacity of vitamin E (50 and 100 M) to enhance the antiplatelet effect of aspirin.
The combination of vitamin E with aspirin is becoming an attractive therapeutic approach to prevent thrombotic vascular accidents.
This finding provides a rationale for combining aspirin and vitamin E to prevent thrombotic complications in atherosclerotic patients.
Haematologica  •  2002  |  View Paper
When alpha-tocopherol (20 micrograms/ml) and aspirin (0.5 mM), or alpha-tocopherol and the mixture of phosphocreatine (1.5 mM) and creatine phosphokinase (50 U/ml) (CP/CPK) were added to this reaction system, a synergic inhibitory effect on aggregation was observed.
Thrombosis research  •  1990  |  View Paper
Preincubation with the lipoxygenase inhibitor 5,8,11,14-eicosatetraynoic acid (ETYA) completely abolished this arachidonate-induced tocopherol oxidation whereas cyclooxygenase inhibitors (indomethacin and aspirin ) further potentiated tocopherol oxidation , indicating that this oxidation is closely linked with platelet 12-lipoxygenase activity.
The Journal of biological chemistry  •  1990  |  View Paper
The total average PI score of the right and left uterine arteries in groups receiving vitamin E in accompanied with aspirin was lower than the two counterparts significantly (p<0.001).
The total average PI score of the right and left uterine arteries in groups receiving vitamin E in accompanied with aspirin was lower than the two counterparts significantly (p<0.001).
The women receiving vitamin E in accompanied with aspirin had the least mean PI of the uterine artery (p<0.001).
International journal of reproductive biomedicine  •  2017  |  View Paper
BackgroundThis experiment was conducted … test the hypothesis that vitamin E (Vit …) and acetylsalicylic acid (ASA), a cyclooxygenase-2 (COX-2) inhibitor, will additively reduce the production of the immunosuppressive molecule prostaglandin E2 (…) and hence reduce inflammatory responses in weaner pigs experimentally infected with an enterotoxigenic strain of E. coli.
Journal of Animal Science and Biotechnology  •  2016  |  View Paper
These effects could be limited by the use of tocopherol and acetylsalicylic acid.
Annals of agricultural and environmental medicine : AAEM  •  2014  |  View Paper
Show More