Possible Interaction: Aspirin and Vitamin C

“In healthy subjects, clinically relevant doses of ASA reduced ASC concentrations in gastric mucosa by about 10% within 6 days resulting from antioxidative defense mechanisms.”

“The addition of vitamin C significantly attenuated gastric damage and reversed the effects of ASA on these parameters.”

“Chemiluminescence increased after aspirin both with placebo (p < 0.05) and vitamin C (p < 0.05).”

“ Ascorbic acid , a quinone reducing agent, and GSH, an antioxidant and quinone trap substrate, prevented ASA cell toxicity.”

“Similar findings were observed in guinea-pigs, where in addition faecal excretion of vitamin C was found to be significantly increased when the vitamin was administered together with aspirin.”

“Endoscopic evaluation has demonstrated that the addition of ascorbic acid to aspirin significantly improves Lanza scores and rates of blood loss when compared to aspirin administration alone.”

“Nevertheless, ascorbic acid may be a viable addition to the strategies employed to improve the gastrointestinal tolerability of aspirin.”

“There is reasonable evidence to support the benefit of the addition of ascorbic acid , an ingredient with antioxidant properties, to moderate the adverse gastrointestinal (GI) effects of aspirin.”

“Further, these experiments suggest that a combination of aspirin with ascorbic acid constitutes a novel approach to render COX-2 more sensitive to inhibition by aspirin, allowing an anti-inflammatory therapy with lower doses of aspirin, thereby avoiding the side effects of the usually high dose aspirin treatment.”

“Furthermore, in combination with aspirin, ascorbic acid augmented the inhibitory effect of aspirin on PGE2 synthesis.”

“By the end of the first week, patients treated with vitamin C plus aspirin had higher vitamin C levels (p = 0.02) and lower 8,12‐iPF2α‐VI levels (p = 0.01) than patients treated with aspirin alone.”

“We conclude that vitamin C , at the dose of 200∼mg/day and in conjunction with aspirin , significantly decreases ischemic stroke‐related lipid peroxidation in humans.”

“We conclude that vitamin C combined with acetylsalicylic acid , unlike plain acetylsalicylic acid without vitamin C, protects gastric mucosa in man probably due the attenuation of oxidative stress and proinflammatory cytokines.”

“ Vitamin C has been shown to reduce gastric toxicity of ASA in humans.”