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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Aspirin
supplement:
Tryptophan
Research Papers that Mention the Interaction
“Plasma gastrin levels were raised in subjects given melatonin or tryptophan plus ASA , but not in those with ASA alone.”
“Plasma melatonin was markedly increased after treatment with melatonin or tryptophan plus ASA , but it was also raised significantly after application of ASA alone.”
Role of melatonin in mucosal gastroprotection against aspirin‐induced gastric lesions in humans“Studies in animals showed that both MT and Trp given intragastrically prevents the formation of gastric mucosal lesions induced by ASA.”
“We concluded that: MT and its precursor Trp significantly attenuate gastric mucosal lesions induced by aspirin.”
“The effects of aspirin on cataract formation may result from 1) lowering of plasma tryptophan levels and increased excretion of tryptophan metabolites, 2) inhibition of aldose reductase and sorbitol formation in the diabetic lens, 3) inhibition of tryptophan or kynurenine binding to lens protein.”
“Analyzing the calculated results revealed that the five member ring of Trp has a key role in interaction of LYS with ASA and CYP.”
Spectroscopic and DFT investigation of interactions between cyclophosphamide and aspirin with lysozyme as binary and ternary systems
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