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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ Acetyl-salicylic acid has been found to inhibit … proteolytic enzymes (fibrinolysin and trypsin ) and phospholipase A. It hampers their hydrolytic action on phospholipids of the blood cells membranes, prevents deformation of … and also averts a fall of the ATP-ase activity of the erythrocytes membranes caused by parachlormercury-benzoate.”
[Mechanism of the action of acetylsalicyclic acid on formed element aggregation].“ Aspirin treatment made the synthase less resistant to trypsin ; aspirin-treated synthase became more resistant to trypsin when it was incubated with indomethacin before addition of the protease.”
Topography of prostaglandin H synthase. Antiinflammatory agents and the protease-sensitive arginine 253 region.“Nearly complete conversion of PGH synthase to 33- and 38-kDa fragments by exposure to high concentrations of trypsin prior to [3H]acetylsalicylic acid treatment results in labeling of the 38-kDa fragment, but not the 33-kDa fragment.”
“Chymotrypsin, trypsin and serratiopeptidase possess antiinflammatory activity and exhibit synergistic effect with aspirin in both acute and subacute models of inflammation in rats.”
Effect of Some Clinically Used Proteolytic Enzymes on Inflammation in Rats
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