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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Aspirin and Sphingosine 1-Phosphate

Research Papers that Mention the Interaction

Since S1P is a potent cardioprotectant, the reduction in its plasma concentration after the loading dose of aspirin could be undesired side effect of the drug.
Advances in medical sciences  •  2013  |  View Paper
We previously described that aspirin has effects beyond inhibition of platelet aggregation, as it inhibited thrombin-mediated release of sphingosine-1-phosphate (S1P) from human platelets.
Pharmacology  •  2017  |  View Paper
By this action, aspirin also inhibits paracrine thromboxane functions on other lipid mediators, such as the platelet storage product sphingosine-1-phosphate (S1P), an inflammatory mediator.
Prostaglandins & other lipid mediators  •  2015  |  View Paper
Oral ASA (500‐mg single dose or 100 mg over 3 days) attenuated S1P release from platelets in healthy human volunteers ex vivo.
Journal of thrombosis and haemostasis : JTH  •  2011  |  View Paper
The results obtained in the present study show aspirin to be a drug with the potential to affect and suppress biofilm formation by Candida spp.,
Therefore, the significant effects of aspirin on growth and biofilm formation of Candida spp.
Journal of chemotherapy  •  2004  |  View Paper