supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Aspirin
supplement:
Sphingosine 1-Phosphate
Research Papers that Mention the Interaction
“Since S1P is a potent cardioprotectant, the reduction in its plasma concentration after the loading dose of aspirin could be undesired side effect of the drug.”
Dose-dependent effect of aspirin on the level of sphingolipids in human blood.“We previously described that aspirin has effects beyond inhibition of platelet aggregation, as it inhibited thrombin-mediated release of sphingosine-1-phosphate (S1P) from human platelets.”
“By this action, aspirin also inhibits paracrine thromboxane functions on other lipid mediators, such as the platelet storage product sphingosine-1-phosphate (S1P), an inflammatory mediator.”
“ Oral ASA (500‐mg single dose or 100 mg over 3 days) attenuated S1P release from platelets in healthy human volunteers ex vivo.”
“The results obtained in the present study show aspirin to be a drug with the potential to affect and suppress biofilm formation by Candida spp.,”
“Therefore, the significant effects of aspirin on growth and biofilm formation of Candida spp.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback