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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ Aspirin , which … serine residue close to the active site,5 has been shown to reduce significantly myocardial infarction and death in four placebocontrolled, double-blind trials.… other pharmacological properties of aspirin are relevant, its efficacy has been explicable in terms of its action as an inhibitor of platelet cyclooxygenase.”
Ticlopidine in unstable angina. A more expensive aspirin?“ Aspirin exerts its unique pharmacological effects by irreversibly acetylating a serine residue in the cyclooxygenase site of prostaglandin-H2-synthases (PGHSs).”
“ Aspirin irreversibly acetylates a serine residue at position 529 in the human enzyme,5 close to but not at the catalytic site, though still blocking access to it by the arachidonic acid substrate.”
“In this work, we have found that in the presence of acetylsalicylic acid , at a concentration like that used for anti-inflammatory treatments, tau phosphorylation at serine 422 decreases.”
“ Aspirin acts by irreversibly acetylating a serine residue at position 530 within the channel, blocking access of arachidonic acid to its catalytic site, and preventing metabolism of arachidonic acid for the lifetime of the platelet (Figure 1B).”
“ Aspirin irreversibly acetylates a serine residue at position 529 in COX-1, preventing arachidonic acid from reaching the binding site.”
“More usefully, the multiple potential causes of treatment failure on aspirin might be pursued and named accordingly.11 Aspirin irreversibly acetylates a serine residue at position 530 on the cyclooxygenase (COX) enzyme, thus inhibiting the first step in the transformation of arachidonic acid to the platelet agonist thromboxane A2.”
“ Aspirin inhibits platelet function by blocking the synthesis of thromboxane A,, a vasoconstrictor and promoter of platelet aggregation, by irreversibly acetylating a serine residue, and thus inhibiting the cyclooxygenase and hydroperoxidase reactions needed for the production of thromboxane A, (6).”
“ Acetylsalicylic acid irreversibly inhibits cyclooxygenase by acetylating a serine residue in the active site.”
“ Aspirin selectively inhibits the fatty acid cyclooxygenase activity but not the PG hydroperoxidase activity by acetylating the serine #506.”
[Molecular structure and regulation of cyclooxygenase].
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