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Last Updated: 2 years ago

Possible Interaction: Aspirin and Melatonin

drug:

Aspirin

supplement:

Melatonin

Research Papers that Mention the Interaction

Overall, the organ and vascular protective qualities of melatonin at the cost of very few or no side-eff ects far exceed those of aspirin , which is much more widely used for cardioprotection than melatonin is.
The Lancet  •  2015  |  View Paper
Plasma gastrin levels were raised in subjects given melatonin or tryptophan plus ASA , but not in those with ASA alone.
We conclude that melatonin and its precursor tryptophan given orally significantly reduce gastric lesions induced by ASA possibly due to (a) direct gastroprotective action of exogenous melatonin or that generated from tryptophan and (b) gastrin released from the gastric mucosa by melatonin or tryptophan.
Journal of pineal research  •  2010  |  View Paper
Studies in animals showed that both MT and Trp given intragastrically prevents the formation of gastric mucosal lesions induced by ASA.
We concluded that: MT and its precursor Trp significantly attenuate gastric mucosal lesions induced by aspirin.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society  •  2008  |  View Paper
The lower basic production of MT is also responsible for a lower content of its metabolite-endogenic acetylsalicylic acid , thereby increasing the sensitivity of melatonin-producing cells, in particular of platelets, to this acid.
Neuro endocrinology letters  •  2002  |  View Paper
We found that melatonin exhibited some healing effects on ASA induced duodenal mucosal injury.
Biotechnic & histochemistry : official publication of the Biological Stain Commission  •  2018  |  View Paper
Moreover, coadministration of MEL and ASA increased antioxidant enzyme activities after the BDL, and these increases were statistically significant for CAT and GPx.
ResultsOur results indicated that BDL caused a significant increase in lipid peroxidation, whereas coadministration of MEL with ASA significantly decreased MDA and NO levels in BDL rats.
Journal of Gastroenterology  •  2006  |  View Paper
ASA treatment decreased significantly the gastric GSH levels, and pretreatment with omeprazole, famotidine, or melatonin increased it significantly.
Gastric LPO and MPO activity that were increased significantly by ASA were decreased after treatment with omeprazole, famotidine, and melatonin.
Omeprazole (20 μmol/kg per os), famotidine (3 mg/kg per os), and melatonin (10 mg/kg intraperitoneally) significantly prevented gastric ulcerogenesis induced by ASA (200 mg/kg per os) and decreased the ulcer index.
Digestive Diseases and Sciences  •  2004  |  View Paper
The presence of MT significantly improved the heat tolerance of wheat seedlings by modulating their antioxidant defense system, activating the ascorbate–glutathione ( AsA –GSH) cycle comprising ascorbate peroxidase (APX), and increasing glutathione reductase (GR) activities.
Plants  •  2020  |  View Paper
Beyond this, MT stimulates the antioxidant enzymes and augments antioxidants, as well as activates the ascorbate–glutathione ( AsA –GSH) cycle to scavenge excess reactive oxygen species (ROS).
Molecules  •  2020  |  View Paper
Additionally, melatonin treatment enhanced the activity of antioxidant enzymes, increased the levels of ascorbic acid, and reduced glutathione levels, which are related to the ascorbate-glutathione cycle, as well as increasing the AsA :DHA and GSH:GSSG ratios.
Food chemistry  •  2019  |  View Paper
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