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Last Updated: 2 years ago

Possible Interaction: Aspirin and Indole-3-Carbinol

drug:

Aspirin

Research Papers that Mention the Interaction

In both cell lines, combinations of aspirin and I3C cooperatively arrested cell proliferation and induced a G1 cell cycle arrest, and nearly ablated protein and transcript levels of the melanocyte master regulator microphthalmia-associated transcription factor isoform M (MITF-M).
In melanoma cells transfected with a −333/+120-bp MITF-M promoter-luciferase reporter plasmid, treatment with aspirin and I3C cooperatively disrupted MITF-M promoter activity, which accounted for the loss of MITF-M gene products.
Cell Biology and Toxicology  •  2016  |  View Paper