Possible Interaction: Aspirin and Homocysteine

“ Hcy levels significantly affected suboptimal response to ASA , but not to ADP-mediated aggregation.”

“ Aspirin (more than 1 mg/l) had more effect on higher concentrations of homocysteine.”

“ Aspirin increased velocity of clot lysis and decreased lysis time of clot in the presence of homocysteine.”

“ Homocysteine at 50 &mgr;mol/l with aspirin (100, 10, and 1 mg/l) had significant changes in all fibrinolysis parameters (P < 0.05), compared to homocysteine at 50 &mgr;mol/l.”

“… homocysteine … aspirin 100 ml/g had significant changes in the lysis maximum velocity (0.150 ± 0.002), half-lysis time (218 ± 5.77), the total lysis … time (278 ± 7.63), the total lysis time (515 ± 14.29), and lag time in lysis (176 ± 3.60), respectively (P < 0.05).”

“ Hcy diminished in vitro antiplatelet effect of low ASA concentration and augmented platelet aggregation (by up to 62% (p<0.005) for coll and up to 15% (p<0.005) for AA), whereas its acetyl derivative acted oppositely.”

“Otherwise, Hcy intensified antiplatelet action of high ASA.”

“There was a significant interaction between high tHcy and aspirin use (OR=0.57, 95% CI=0.36–0.91), but not between high tHcy and B-vitamin use (OR=0.80, 95% CI=0.26–2.46).”

“Conclusion Discordant results from MTHFR studies and randomised trials could be explained by aspirin reducing or negating the anti-platelet effect of lowering homocysteine.”

“Proliferation‐induced homocysteine formation and in parallel also monocyte activation can be suppressed effectively by aspirin and salicylic acid in vitro, suggesting that also in vivo aspirin may downregulate not only inflammation but also formation of homocysteine.”

“ Acetylsalicylic acid totally prevented the effect of homocysteine on acetylcholinesterase activity and catalase activity and immunocontent, as well as the ultrastructural changes, and partially prevented alterations on IL-1β levels, superoxide dismutase activity, sulfhydryl content, and comet assay.”

“In summary, our findings showed that chronic chemically induced model of mild hyperhomocysteinemia altered some parameters and acetylsalicylic acid administration seemed to be neuroprotective, at least in part, on neurotoxicity of homocysteine.”