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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Substitution of …-513 with histidine (the equivalent residue in COX-1) resulted in a 2-fold potentiation of aspirin inhibition, in support of the hypothesis that the presence of histidine in COX-1 lowers the activation barrier associated with the formation of the initial non-covalent enzyme-inhibitor complex.”
Arg-513 and Leu-531 Are Key Residues Governing Time-Dependent Inhibition of Cyclooxygenase-2 by Aspirin and Celebrex.“Modification of histidine and lysine residues of the enzyme with diethyl pyrocarbonate and acetylsalicylic acid , respectively, inactivated the enzyme.”
Inactivation of bakers' yeast glucose-6-phosphate dehydrogenase by aluminum.“L-Methionine and histidine markedly reduced aspirin stability.”
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