Possible Interaction: Aspirin and Glutathione

“ ASA led to significant intracellular GSH depletion in melanocytic SK-MEL-28 melanoma cells but not in amelanotic C32 melanoma cells.”

“Ascorbic acid, a quinone reducing agent, and GSH , an antioxidant and quinone trap substrate, prevented ASA cell toxicity.”

“ Aspirin exacerbates this by depleting glutathione that would detoxify the reactive intermediates.”

“We have also shown that some of the effects of aspirin might be associated with reduced GSH homeostasis, as treatment of cells with NAC attenuated the effects of BSO and aspirin.”

“ Aspirin exacerbates this by depleting glutathione that would detoxify the reactive intermediates.”

“Our findings indicate that the IC50 (48 h) for ASA in B16-F0 melanoma cells was 100 μM and that ASA caused a dose- and time-dependent GSH depletion and increase in reactive oxygen species (ROS) formation in B16-F0 melanoma cells.”

“ ASA significantly increased MDA levels in both kidney and testis, whereas it significantly decreased the values of SOD, CAT, GPX, and GSH in kidney and CAT levels in testis.”

“The oral administration of ASA decreased catalase (CAT), reduced glutathione ( GSH ), and increased lipid peroxidation (LPO) levels.”

“ Aspirin treatment significantly decreased lipid peroxidation and significantly increased reduced glutathione content.”

“… aspirin for 7 days significantly improved motor function and attenuated the raised … +/- 17.3 nmol/g tissue, respectively) and the decrease in GSH (101 +/- 5 and 100 +/- 4.5 microg/g tissue, respectively) and SOD (12.….6 U/mg protein, respectively), as compared to vehicle-treated MCA occluded rats.”

“ ASA treatment decreased significantly the gastric GSH levels, and pretreatment with omeprazole, famotidine, or melatonin increased it significantly.”