Possible Interaction: Aspirin and Glutamine

“Otherwise, the non-steroidal anti-inflammatory drugs nimesulide, acetylsalicylic acid , ibuprofen, and diclofenac sodium decreased the extracellular glutamate and glutamine levels, downregulated GS and AChE activities, and restored ACh levels in Pro-treated astrocytes.”

“The results of Okabe et al (1974a,b) and of Tanaka et al (1974) clearly suggest that L-glutamine administration can, probably by inhibition of back diffusion of acid, prevent the formation of gastric lesions produced by aspirin in the rat.”

“ Oral glutamine inhibited lesion production in all three systems whereas aspirin orally markedly potentiated it.”

“ L-glutamine also prevented in varying degrees the reduction of acid and increment of Na+ ion in gastric juice accumulated in stressed rats in response to ASA or TCA.”

“However, when L-glutamine 2.0 or 4.0 g per dog in two divided doses is given concomitantly with ASA 2.0 g per dog orally, the gastric irritation is significantly inhibited.”

“When L-glutamine (100 mM) was given concomitantly with ASA (20 mM) into the pouch, changes of electrolyte fluxes in response to ASA alone were significantly suppressed.”

“Blood salicylate level in these rats was higher when aspirin was administered in combination with L-glutamine than when it had been given alone.”

“ L-glutamine markedly suppressed the development of the gastric lesions induced by aspirin in pylorus-ligated rats.”

“ L‐Glutamine had a pronounced inhibitory effect on gastric lesions induced by aspirin administered by oral, intraperitoneal, or intraduodenal routes to intact or pylorus‐ligated rats.”

“One mechanism of L‐glutamine protection was inhibition of a back diffusion of gastric acid caused by aspirin and this was demonstrated in pylorus‐ligated rats.”